The focus of this book is on labelling and on the production of labelled compounds and/or samples. The book does not cover the theory of mass spectrometry. However, the authors do introduce into the book the theory of mass spectrometry and of isotope dilution as a technique and its applications within the different areas of analytical chemistry. The emphasis of the book is on practical aspects, such as laboratory work, instrumentation, sample preparation, and data processing. Applications in the field of organic analysis (e.g. biomolecules), biochemical analysis, traceability of goods and in clinical chemistry are included. Some practical aspects, such as practical methods and sample preparation and data processing, are not covered in detail; they are presented in an easy-to-understand way for all laboratory and analytical chemists.
The book will be of interest to researchers working with mass spectrometry, especially those in analytical chemistry and geochemistry; chemists and biologists who use isotope dilution analyses and isotope ratio mass spectrometry for elemental and organic analysis; and chemists who need to understand isotope dilution mass spectrometry for the preparation of various labeled compounds. Students, educators, administrators and scientists in industry in or affiliated to this area will also find this book useful.
This book is divided into three parts. The first part gives an introduction to Isotope Dilution and includes the theory of isotope dilution and isotope ratio mass spectrometry. Part I also contains general chapters on isotope dilution in analytical chemistry and general aspects of isotope dilution. The rest of the book is devoted to practical aspects of Isotope Dilution Mass Spectrometry (IDMS) with data presented in the form of flow diagrams. The second part provides the details of the labelling and sample preparation procedures and the data interpretation with suggestions for further reading.
The book starts with a short introduction to Isotope Dilution. The author of this book made a significant contribution to the development of the theory and applications of this technique. He is the founder of the International Atomic Energy Agency (IAEA) and the International Society for Isotope Dilution in Environmental and Life Sciences. The book is dedicated to his memory. The last chapter is devoted to recent developments in the field of Isotope Dilution Mass Spectrometry with a special focus on biological applications.
Isotope Dilution Mass Spectrometry has been published in a Spanish edition with the name Isotopía Envia: Metodología y Aplicaciones (2nd edition, Editorial Universitaria, 2013) that includes all the chapters and the almost 300 figures, tables and graphs. This book is the first English edition and will be of interest for readers who want to learn more about the theory of Isotope Dilution Mass Spectrometry and the applications in their own or affiliated laboratories. It will also be useful for postgraduate students and researchers in Chemistry, Chemical Engineering, Biochemistry and Biology, Environmental and Biological Sciences and Medicine interested in isotope dilution techniques and isotope analysis. In addition, the book will be useful for researchers or other scientists working in other fields such as Geology, Geochemistry, Archaeology, Physics, Chemistry, Biochemistry and Clinical Research who are using Isotope Dilution Mass Spectrometry in their work. 827ec27edc