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Therapeutic efficacy of diflucan (antifungal) was shown in numerous studies in patients suffering from systemic candidiasis and vaginal candidiasis. Antifungal effects of diflucan are based on the inhibition of synthesis of fungal macromolecules, mainly DNA and ergosterol. The therapeutic efficacy of diflucan (250 mg twice daily for 7 days) in patients with AIDS-associated systemic candidiasis was significantly higher than that of amphotericin B (300 mg/day for 7 days) and flucytosine (100 mg/kg/day for 7 days). The clinical efficacy of diflucan (125 mg/twice a day for 7 days) was comparable to that of fluconazole (250 mg/day for 7 days) in patients with vulvovaginal candidiasis. The efficacy of diflucan in pediatric patients with acute lymphoblastic leukemia was comparable to that of amphotericin B. Clinical studies of diflucan in immunocompromised patients with other mycoses showed that the efficacy of this agent was comparable to that of ketoconazole and itraconazole. Gastrointestinal adverse events (nausea, vomiting and abdominal pain) were more frequent with diflucan than with fluconazole. Diflucan is effective in the treatment of systemic candidiasis and vulvovaginal candidiasis and is a well-tolerated drug.1. Field of the Invention

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