In 2015, Menen starred in numerous films which gave her more critical and commercial recognition. In the beginning of the year, she paired up with Sharwanand for the Telugu movie, Malli Malli Idi Rani Roju, a love story between a Muslim girl and a Hindu boy which is tragically separated by fate. Her performance as Nazeera, the young Muslim student in love who later becomes a successful businesswoman in Malaysia was well praised by the critics eventually receiving her Filmfare Critics Award for Best Actress South, Nandi Special Jury Award and also receiving her second nomination at Filmfare. With this Menen became the first Telugu actress ever to win Critics Award & the Best Actress Award at Filmfare. She did minor roles in the films S/O Satyamurthy directed by Trivikram Srinivas, Kanchana 2 directed by and starring Raghava Lawrence and Rudhramadevi where she shared scenes with Anushka Shetty. She appeared opposite Dulquer Salmaan in two films in 2015, 100 Days of Love, a romantic Malayalam film and OK Kanmani, a Tamil film directed by Mani Ratnam which explored a live-in relationship between a male video game designer and a female architectural student. Dulquer and Menen's on-screen chemistry was praised in the reviews of both films. For OK Kanmani, she received near universal acclaim for her role as Tara and garnered her first Filmfare Award for Best Tamil Actress nomination.
In 2022, Menen starred in Bheemla Nayak opposite Pawan Kalyan, where she was praised by critics for portraying the powerful role as Nayak wife and the movie grossed over 160 cr at box office. Later she shared screen with Revathi in Modern Love Hyderabad which explores the estranged relationship (due to an interfaith marriage) between a mother and daughter where Menen performance as Noori Hussain was highly praised. Later she appeared in romantic drama film Thiruchitrambalam opposite Dhanush as his childhood best friend Shobana where a review from The News Minute complimented her performance. Nithya got 2-3 offers to act with Dhanush before this film, including for Aadukalam but she couldn't do that because of other reasons. Dhanush also planned to direct a movie in 2018 which would have Nithya collaborating with him, but again that project didn't materialize. While writing the script for Thiruchtrambalam Dhanush had Nithya in mind for the lead role. The film became a critical and commercial success at the box office and grossed over 100 cr. 2b1af7f3a8