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One must consider two effects of radiation exposure to the hematopoietic system: the induction of mutations in hematopoietic stem cells, and, secondary to this, a progressive depletion of immature progenitor cells, which will eventually lead to a reduction in bone marrow capacity to produce mature cells. Evidence is presented that the former effect is proportional to the mutagenic effect of radiation, as measured in vitro, whereas the second effect correlates inversely to the mutagenic effect, since cells with higher differentiation stages are more radioresistant and show a lesser depletion of progenitor cells in vivo. This evidence is based on data obtained with x-ray doses ranging from 1 to 6 Gy, and with exposure times of 4, 7, 12 and 28 days. The possible clinical relevance of this observation is discussed.Q:

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